Research Explorer

Project

Study of the (patho)physiological role of NF-kB inhibitors A20 and ABINs through genetic
Code
3G091908
Duration
01 July 2007 → 30 June 2014
Funding
Research Foundation - Flanders (FWO)
Research disciplines
  • Natural sciences
    • Genetics
    • Systems biology
  • Medical and health sciences
    • Immunology
    • Molecular and cell biology
    • Morphological sciences
    • Oncology
    • Physiology
    • Immunology
    • Morphological sciences
    • Oncology
    • Physiology
    • Immunology
    • Molecular and cell biology
    • Morphological sciences
    • Oncology
    • Physiology
Keywords
ABIN NF-kB gene targeting A20 disease apoptosis
 
Project description
 

The aim of the Odysseus project is to understand the function, activation and regulation of NF-kB activation and apoptosis by A20 and A20-interacting ABIN proteins, using conditional gene targeting in the mouse in combination with mouse models of human diseases. Such knowledge may lead to novel approaches to prevent and treat various inflammatory and degenerative disorders.