Project

Translational research into the role of Damage Associated Molecular Patterns in the pathogenesis of Chronic Obstructive Pulmonary Disease (COPD)

Duration
01 January 2010 → 31 December 2015
Funding
Research Foundation - Flanders (FWO)
Research disciplines
  • Medical and health sciences
    • Respiratory medicine
    • Respiratory medicine
    • Respiratory medicine
Keywords
DAMPs COPD cigarette smoke
 
Project description

Both in a murine model of COPD, and in patients with COPD (compared with smokers without airway obstruction) we will investigate the expression and functional role of Damage Associated Molecular Patterns in the pathogenesis of Chronic Obstructive Pulmonary Disease (COPD). In the murine model of COPD, using specific knock-out (KO) mice, we will investigatee the effect of DAMPs on the acute inflammation in the lungs and airways after 4 weeks exposure to cigarette smoke (CS) after 6 months exposure to air or CS, the effects of DAMPs will be investigated on inflammation, emphysema, lymphoid neogenesis and airway wall remodeling.