Project

High-Precision Mapping of HLA Gene Links to Clozapine-Induced Neutropenia via Long-Read Amplicon Sequencing with Double UMIs

Code
01CD05325
Duration
01 March 2026 → 31 October 2026
Funding
Regional and community funding: Special Research Fund
Research disciplines
  • Medical and health sciences
    • Biomarker evaluation
    • Pharmacodynamics
    • Pharmogenetics and -genomics
Keywords
Double UMIs schizophrenia HLA next generation sequencing
 
Project description
The risk of developing clozapine-induced neutropenia is closely linked to the duration of drug therapy, with the majority of cases occurring within the first 18 weeks. This study explores the use of double unique molecular identifiers (UMIs) combined with high-accuracy long-read nanopore sequencing for HLA gene analysis, annotation of HLA gene variants and evaluating their associations with adverse reaction to clozapine.