Project

An ontogenic pig model as human pediatric surrogate for preclinical pharmacokinetic and pharmacodynamic drug testing.

Duration
01 October 2014 → 30 September 2017
Funding
Regional and community funding: Special Research Fund, Research Foundation - Flanders (FWO)
Research disciplines
  • Natural sciences
    • Animal biology
  • Medical and health sciences
    • Biomarker discovery and evaluation
    • Drug discovery and development
    • Medicinal products
    • Pharmaceutics
    • Pharmacognosy and phytochemistry
    • Pharmacology
    • Pharmacotherapy
    • Toxicology and toxinology
    • Other pharmaceutical sciences
  • Agricultural and food sciences
    • Veterinary medicine
    • Other veterinary sciences
    • Other agricultural, veterinary and food sciences
Keywords
animal model drug design pediatrics pig
 
Project description

Drug study designs adapted to the pediatric population are lacking up until now. The primary reason is the absence of representative preclinical methods and animal models that accurately reflect the age-based changes observed in infants. Because of the striking similarities in anatomy and physiology between humans and pigs, the suitability of pigs as a pediatric animal model will be evaluated.