Project

The why, when and how of platelet GPIbα ectodomain shedding

Code
01D19922
Duration
01 November 2022 → 31 October 2026
Funding
Regional and community funding: Special Research Fund
Research disciplines
  • Medical and health sciences
    • Hematology
Keywords
Receptor shedding platelets glycocalicin
 
Project description

The role of GPIbα shedding and glycocalicin release by ADAM17 is unknown. During this mandate, we will investigate where and when GPIbα shedding occurs in models of haemostasis. The role of glycocalicin will be further unraveled. Neutrophils strongly bind to GPIbα and this project will investigate how (trans)migration of neutrophils is inflenced by glycocalicin using models of haemostasis.