Code
01D13322
Duration
14 November 2022 → 31 October 2023
Funding
Regional and community funding: Special Research Fund
Promotor
Research disciplines
-
Agricultural and food sciences
- Veterinary immunology
- Veterinary oncology
- Veterinary physiology, pathophysiology and biochemistry
Keywords
Canine B cell lymphoma
immunotherapy
biomarker profiling
Project description
The number of non-chemoresponsive B cell lymphoma (BCL) canine patients is increasing. Through immunophenotyping of lymph nodes and blood, novel markers will be identified that can improve the diagnosis and prognosis of BCL. The potential of these markers as target for neoantigen immunotherapy will be evaluated via the synthesis of nanobodies, whose efficacy will be investigated in a 3D BCL-model.