Project

Unraveling the role of PHF6 in normal T-cell development and T-cell acute leukemia

Duration
01 October 2010 → 30 November 2014
Funding
Regional and community funding: Special Research Fund
Research disciplines
  • Natural sciences
    • Systems biology
  • Medical and health sciences
    • Hematology
    • Laboratory medicine
    • Medical systems biology
    • Morphological sciences
    • Oncology
    • Hematology
    • Laboratory medicine
    • Medical systems biology
    • Molecular and cell biology
    • Morphological sciences
    • Oncology
    • Hematology
    • Laboratory medicine
    • Medical systems biology
    • Molecular and cell biology
    • Morphological sciences
    • Oncology
Keywords
T-ALL T-cells PHF6 leukemia
 
Project description

T-ALL results from malignant transformation of thymocytes. Although treatment outcome has improved, many factors contributing to T-ALL development remain unknown. Recently, PHF6 was identified as a novel tumor suppressor gene in the pathogenesis of T-ALL at our lab. The aim of this project is to investigate the cellular function of PHF6 and its role in normal T-cell and T-ALL development