Project

The protective effect of exercise on diabetic nephropathy: role of histidyl dipeptides

Code

01J06515

Duration

01 September 2015 → 30 June 2020

Funding

Regional and community funding: Special Research Fund

Promotor

Wim Derave

Research disciplines

Social sciences
- Education curriculum
Medical and health sciences
- Endocrinology and metabolic diseases
- Physiology
- Endocrinology and metabolic diseases
- Physiology
- Endocrinology and metabolic diseases
- Physiology

Keywords

Diabetic nephropathy exercise carnosine

Project description

We aim to elucidate the role of exercise-induced histidyl dipeptides on development of diabetic nephropathy. The effect of supplementation and exercise, two ways to enhance circulating dipeptides, will be investigated in BTBR ob/ob mice, genetically manipulated for human dipeptide-degrading enzyme (carnosinase). We further investigate dipeptide-related potential biomarkers to predict the progression of diabetic nephropathy in humans.