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Project

the spreading mechanisms and responsible messengers of the radiation induced bystander effect

Outputs and Outcomes

Code

3F012415

Duration

01 October 2015 → 30 September 2019

Funding

Research Foundation - Flanders (FWO)

Promotor

Luc Leybaert

Fellow

Delphine Hoorelbeke

Research disciplines

Medical and health sciences
- Medical imaging and therapy
- Physiology
- Medical imaging and therapy
- Physiology
- Medical imaging and therapy
- Physiology

Keywords

irradiation gap junctions messengers

Project description

The damage induced by ionizing radiation can spread to non-exposed bystander cells. We hypothesize that an initial ROS production in the irradiated cells is transmitted via calcium waves, propagated by ATP, to neighbouring cells, were the calcium in turn induces a ROS production. Next to that we will also investigate the effect of radiation on connexin-expression and the ER-mitochondria distance.

English

Dutch

English

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