Project

the spreading mechanisms and responsible messengers of the radiation induced bystander effect

Duration
01 October 2015 → 30 September 2019
Funding
Research Foundation - Flanders (FWO)
Research disciplines
  • Medical and health sciences
    • Medical imaging and therapy
    • Physiology
    • Medical imaging and therapy
    • Physiology
    • Medical imaging and therapy
    • Physiology
Keywords
irradiation gap junctions messengers
 
Project description

The damage induced by ionizing radiation can spread to non-exposed bystander cells. We hypothesize that an initial ROS production in the irradiated cells is transmitted via calcium waves, propagated by ATP, to neighbouring cells, were the calcium in turn induces a ROS production. Next to that we will also investigate the effect of radiation on connexin-expression and the ER-mitochondria distance.