Project

Genome wide study of mutations in murine neuroblastoma models

Duration
01 October 2012 → 30 September 2013
Funding
Funding by bilateral agreement (private and foundations)
Research disciplines
  • Natural sciences
    • Genetics
    • Systems biology
  • Medical and health sciences
    • Molecular and cell biology
    • Morphological sciences
    • Oncology
    • Pediatrics and neonatology
    • Morphological sciences
    • Oncology
    • Pediatrics and neonatology
    • Nursing
    • Molecular and cell biology
    • Morphological sciences
    • Oncology
    • Pediatrics and neonatology
Keywords
neuroblastoma pediatrics next generation sequencing cancer
 
Project description

Cancer mouse models are becoming indispensible tools in the study of human cancer. As the behavior of these murine tumors often mimics that of its human counterpart very well, it is currently one of the best resources for testing new therapeutic paradigms. High-throughput genomic profiling and next generation sequencing will be used to analyse the tumors derived form the murine neuroblastoma models. By doing so, we hope to find additional mutations in a tumor with a known strong genetic driver and expect to fain new insights in the pathogenesis of neuroblastoma and to reveal new therapeutic targets.