Sjögren’s Syndrome Pathophysiology Investigating Trial: the SSPIT concept

01 October 2021 → Ongoing
Regional and community funding: Special Research Fund
Research disciplines
  • Medical and health sciences
    • Autoimmunity
    • Autoimmunity
    • Inflammation
    • Transcription and translation
    • Epidemiology
Sjögren’s syndrome Autoimmunity Endotypes Immunobiology of clinical heterogeneity Rheumatology
Project description

This project focuses on underlying mechanisms leading to onset of primary Sjogren’s syndrome with focus on transition of asymptomatic autoantibody positive individuals to full blown disease. We will examine glycosylation profiles of autoantibodies and perform high end flowcytometry and singlecell
RNA sequencing in various phases of the disease. This will permit to delineate the ideal stage for immune intervention.