Project

Sjögren’s Syndrome Pathophysiology Investigating Trial: the SSPIT concept

Code
01D30421
Looptijd
01-10-2021 → 31-10-2022
Financiering
Regional and community funding: Special Research Fund
Onderzoeksdisciplines
  • Medical and health sciences
    • Autoimmunity
    • Autoimmunity
    • Inflammation
    • Transcription and translation
    • Epidemiology
Trefwoorden
Syndroom van Sjögren Auto-immuniteit Endotypes Immuunbiologische basis van klinisch heterogeniteit Reumatologie
 
Projectomschrijving

This project focuses on underlying mechanisms leading to onset of primary Sjogren’s syndrome with focus on transition of asymptomatic autoantibody positive individuals to full blown disease. We will examine glycosylation profiles of autoantibodies and perform high end flowcytometry and singlecell
RNA sequencing in various phases of the disease. This will permit to delineate the ideal stage for immune intervention.