Project

Sjögren’s Syndrome Pathophysiology Investigating Trial: the SSPIT concept

Code
01D30421
Duration
01 October 2021 → 30 September 2025
Funding
Regional and community funding: Special Research Fund
Research disciplines
  • Medical and health sciences
    • Autoimmunity
    • Autoimmunity
    • Inflammation
    • Transcription and translation
    • Epidemiology
Keywords
Sjögren’s syndrome Autoimmunity Endotypes Immunobiology of clinical heterogeneity Rheumatology
 
Project description

This project focuses on underlying mechanisms leading to onset of primary Sjogren’s syndrome with focus on transition of asymptomatic autoantibody positive individuals to full blown disease. We will examine glycosylation profiles of autoantibodies and perform high end flowcytometry and singlecell
RNA sequencing in various phases of the disease. This will permit to delineate the ideal stage for immune intervention.