Code
01GC2110
Duration
01 January 2010 → 17 May 2016
Funding
Regional and community funding: Special Research Fund
Promotor
Research disciplines
-
Natural sciences
- Animal biology
-
Medical and health sciences
- Immunology
- Immunology
- Biomarker discovery and evaluation
- Drug discovery and development
- Medicinal products
- Pharmaceutics
- Pharmacognosy and phytochemistry
- Pharmacology
- Pharmacotherapy
- Toxicology and toxinology
- Other pharmaceutical sciences
- Immunology
-
Engineering and technology
- Process engineering
- Polymeric materials
-
Agricultural and food sciences
- Veterinary medicine
- Other veterinary sciences
- Other agricultural and food sciences
Keywords
mucosal
vaccination
immunology
Project description
This project aims to study early events in the interaction of antigens/microorganisms with epithelial cells and intestinal dendritic cells (DCs). Tolerogenic (ovalbumin), immunogenic (F4 fimbriae, CT and CT-B) as well as the less immunogetic F18 fimbriae will be used as antigens and the pathogenic F4+enterotoxigenic E.coli, F18+verotoxigenic E.coli as well as the non-pathogenic E. coli HB101 and Lactococcus Lactis. A genomic wide approach with the pig microarray of Affymetrix will be used to study the early responses and dual photon-microscopy to study the passage of antigens/microorganisms through the epithelial barrier and their uptake by DCs.