Project

The role of the RANKL/RANK/OPG pathway in the cross talk between synovial fibroblasts and synovial myeloid cells in erosive hand osteoarthritis.

Code
01D19321
Duration
01 October 2021 → 30 September 2025
Funding
Regional and community funding: Special Research Fund
Research disciplines
  • Medical and health sciences
    • Musculo-skeletal systems
Keywords
Hand osteoarthritis Synovium RANKL/RANK/OPG pathway
 
Project description

Erosive hand osteoarthritis is a unique subset of osteoarthritis. Current knowledge on its pathogenesis is limited. Our clinic has mastered a new technique, making it possible to retrieve synovial tissue from finger joints for molecular analysis. This project aims to unravel the
role of RANKL and the crosstalk between synovial fibroblasts and myeloid cells in erosive hand osteoarthritis.