Project

Formulation of ultrasmall vaccine nanoparticles

Duration
01 October 2012 → 30 September 2016
Funding
Regional and community funding: Special Research Fund
Research disciplines
  • Medical and health sciences
    • Immunology
    • Immunology
    • Immunology
  • Engineering and technology
    • Chemical product design and formulation
    • Process engineering
    • Polymeric materials
    • Biomaterials engineering
Keywords
polymers dendritic cells nanoparticles vaccines
 
Project description

In this projact we aim to design ultra small vaccine nanoparticles based on amphiphilic block copolymers that self-assemble in aqueos medium to sub 100 nm micelles. These micelles will be decorated with (1) antigens, (2) a targeting ligand to reach specific DC subsets that are specialized in antigen presenting to CD 8 T cells and (3) immune-stimulatory ligands to further boost the immune response.