Research Explorer

Project

A nanobody-based anti-inflammatory treatment against Pseudomonas aeruginosa-induced inflammation in chronic lung diseases
Code
01D03921
Duration
01 October 2021 → 31 October 2021
Funding
Regional and community funding: Special Research Fund
Research disciplines
  • Natural sciences
    • Bacteriology
    • Infectious diseases
  • Medical and health sciences
    • Inflammation
    • Respiratory medicine
Keywords
Chronic lung disease Pseudomonas aeruginosa anti-inflammatory treatment nanobodies
 
Project description
 

Chronic lung inflammation by Pseudomonas aeruginosa is an important driver of pathogenesis in patients with cystic fibrosis (CF). The objective of this project is to develop an effective therapy against P. aeruginosa-induced chronic lung inflammation, by targeting bacterial pro-inflammatory mediators expressed in vivo, using nanobodies.