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Project

Rational design of biologics for therapeutic development (FoldCo)

Information

Project Team

Outputs and Outcomes

Publications

Activation of goblet-cell stress sensor IRE1β is controlled by the mucin chaperone AGR2

Eva ClootsPhaedra GuilbertMathias ProvostLisa NeidhardtEvelien Van De VeldeFarzaneh FayazpourDelphine De SutterSavvas SavvidesSven EyckermanSophie Janssens

A1 Journal Article in EMBO JOURNAL

2024

Protein citrullination and NET formation do not contribute to the pathology of A20/TNFAIP3 mutant mice

Karel Van DammePieter HertensArne MartensElisabeth GilisDario PriemInge BruggemanAmelie FossoulJozefien DeclercqHelena Catharine AegerterAndy WullaertTino HochepiedEsther HosteLieselotte Vande WalleMohamed LamkanfiSavvas SavvidesDirk ElewautBart LambrechtGeert van Loo et al.

A1 Journal Article in SCIENTIFIC REPORTS

2023

Improving de novo protein binder design with deep learning

Nathaniel R. BennettBrian CoventryInna GoreshnikBuwei HuangAza AllenDionne VafeadosYing Po PengJustas DauparasMinkyung BaekLance StewartFrank DiMaioSteven De MunckSavvas SavvidesDavid Baker et al.

A1 Journal Article in NATURE COMMUNICATIONS

2023