Project

Analysis and mining of signaling complexes using contemporary interactomics

Code

120C05712

Duration

01 April 2012 → 31 December 2017

Funding

Federal funding: various

Promotor

Jan Tavernier

Research disciplines

Natural sciences
- Biochemistry and metabolism
- Systems biology
Medical and health sciences
- Medical biochemistry and metabolism
- Medical biochemistry and metabolism
- Medical biochemistry and metabolism

Keywords

protein interaction networks nanobodies bioinformatics

Project description

Protein interactions fulfil a critical role in a cell and their dysregulation contributes to human disease. We will apply an unique technology “toolbox” comprising MAPPIT, PPI-iMixPro and VIROTRAP, combined with state-of-the-art bioinformatics approaches, to gain new insights into the (patho)fysiological roles of selected protein interactions. In addition, we will use nanobodies as intrabodies to disturb protein interactions in cellulo.