Immune profiling and the role of monocyte/macrophage populations in primary sclerosing cholangitis and related ulcerative colitis.

01 October 2021 → 31 October 2021
Regional and community funding: Special Research Fund
Research disciplines
  • Medical and health sciences
    • Gastro-enterology
    • Hepatology
    • Inflammation
    • Innate immunity
    • Gastro-enterology and hepatology not elsewhere classified
Primary sclerosing cholangitis ulcerative colitis macrophages gut-liver axis
Project description

Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease frequently associated with intestinal inflammation, mainly ulcerative colitis. The etiopathogenesis has not been elucidated but compromises in the gut-liver crosstalk are suggested in which macrophages are implemented. The immunological profile and importance of monocyte-/macrophage-populations will be investigated, including the role of macrophage-Trem2, a recently identified marker in experimental PSC/colitis.