Research Explorer

Project

Humanized mice as a model for the study of Hepatitis E virus (HEV) infection
Code
01DI5816
Duration
01 September 2016 → 30 June 2018
Funding
Regional and community funding: Special Research Fund
Research disciplines
  • Natural sciences
    • Microbiology
    • Systems biology
  • Medical and health sciences
    • Gastro-enterology and hepatology
    • Immunology
    • Laboratory medicine
    • Microbiology
    • Gastro-enterology and hepatology
    • Immunology
    • Laboratory medicine
    • Microbiology
    • Gastro-enterology and hepatology
    • Immunology
    • Laboratory medicine
    • Microbiology
Keywords
gene expression antiviral therapy chimeric mice hepatitis E
 
Project description
 

During this project we have shown that mice of which the liver is repopulated with primary human hepatocytes are susceptible to a hepatitis E virus (HEV) infection. In addition we showed that the host’s gene expression profile is considerably changed upon viral infection. We now want to further dissect the influence of HEV on the hepatic gene expression profile.