Project

Differences in DNA methylation patterns, distinct from normal age and breed-specific changes, affect the feline hypertrophic cardiomyopathy phenotype.

Code

01D24718

Duration

01 October 2018 → 30 September 2022

Funding

Regional and community funding: Special Research Fund

Promotor

Luc Peelman

Fellow

Tom Schipper

Research disciplines

Natural sciences
- Animal biology not elsewhere classified
- Genetics not elsewhere classified
- Systems biology not elsewhere classified
Medical and health sciences
- Cardiac and vascular medicine not elsewhere classified
- Molecular and cell biology not elsewhere classified
- Cardiac and vascular medicine not elsewhere classified
- Cardiac and vascular medicine not elsewhere classified
- Molecular and cell biology not elsewhere classified
Agricultural and food sciences
- Veterinary medicine not elsewhere classified
- Other veterinary sciences not elsewhere classified
- Agricultural, veterinary and food sciences not elsewhere classified

Keywords

Hypertrophic cardiomyopathy (HCM) cat epigenetics DNA methylation whole exome sequencing animal model biomarker

Project description

Whole exome sequencing will be used for the first time in cats to identify HCM-causing mutation(s) in British Shorthair cats. Next, DNA methylation patterns will be analyzed to check if specific epigenetic changes are linked to HCM and whether patterns present in blood cells can also be used as biomarker for HCM.