Project

Differences in DNA methylation patterns, distinct from normal age and breed-specific changes, affect the feline hypertrophic cardiomyopathy phenotype.

Duration
01 October 2018 → Ongoing
Funding
Regional and community funding: Special Research Fund
Promotor
Research disciplines
  • Natural sciences
    • Animal biology
    • Genetics
    • Systems biology
  • Medical and health sciences
    • Cardiac and vascular medicine
    • Molecular and cell biology
    • Cardiac and vascular medicine
    • Cardiac and vascular medicine
    • Molecular and cell biology
  • Agricultural and food sciences
    • Veterinary medicine
    • Other veterinary sciences
    • Other agricultural, veterinary and food sciences
Keywords
Hypertrophic cardiomyopathy (HCM) cat epigenetics DNA methylation whole exome sequencing animal model biomarker
 
Project description

Whole exome sequencing will be used for the first time in cats to identify HCM-causing mutation(s) in British Shorthair cats. Next, DNA methylation patterns will be analyzed to check if specific epigenetic changes are linked to HCM and whether patterns present in blood cells can also be used as biomarker for HCM.