Research Explorer

Project

Role of intestinal barrier dysfunction for the pathogenesis of spondyloarthritis
Code
01D01718
Duration
01 October 2018 → 30 September 2022
Funding
Regional and community funding: Special Research Fund
Research disciplines
  • Medical and health sciences
    • Adaptive immunology
    • Laboratory medicine not elsewhere classified
    • Orthopaedics not elsewhere classified
    • Palliative care and end-of-life care
    • Regenerative medicine not elsewhere classified
    • Other basic sciences not elsewhere classified
    • Autoimmunity
    • Laboratory medicine not elsewhere classified
    • Orthopaedics not elsewhere classified
    • Regenerative medicine not elsewhere classified
    • Other clinical sciences not elsewhere classified
    • Other health sciences not elsewhere classified
    • Nursing not elsewhere classified
    • Other paramedical sciences not elsewhere classified
    • Immunology not elsewhere classified
    • Laboratory medicine not elsewhere classified
    • Regenerative medicine not elsewhere classified
    • Other translational sciences not elsewhere classified
    • Other medical and health sciences not elsewhere classified
Keywords
spondyloarthritis gut inflammation bacterial dysbiosis mucosal barrier
 
Project description
 

Patients with spondyloarthritis (SpA), a chronic inflammatory rheumatic disease, usually present with an altered composition of intestinal microbiota (dysbiosis). We want to investigate how dysbiosis influences gut epithelial integrity and the subepithelial immune system. Furthermore we will correlate the local effects of dysbiosis with biomarker profiles, acting as surrogate indicators of gut inflammation and bacterial translocation.