Project

Role of intestinal barrier dysfunction for the pathogenesis of spondyloarthritis

Duration
01 October 2018 → Ongoing
Funding
Regional and community funding: Special Research Fund
Research disciplines
  • Medical and health sciences
    • Immunology
    • Laboratory medicine
    • Orthopaedics
    • Palliative care and end-of-life care
    • Regenerative medicine
    • Other basic sciences
    • Immunology
    • Laboratory medicine
    • Orthopaedics
    • Palliative care and end-of-life care
    • Regenerative medicine
    • Other clinical sciences
    • Other health sciences
    • Nursing
    • Other paramedical sciences
    • Immunology
    • Laboratory medicine
    • Orthopaedics
    • Palliative care and end-of-life care
    • Regenerative medicine
    • Other translational sciences
    • Other medical and health sciences
Keywords
spondyloarthritis gut inflammation bacterial dysbiosis mucosal barrier
 
Project description

Patients with spondyloarthritis (SpA), a chronic inflammatory rheumatic disease, usually present with an altered composition of intestinal microbiota (dysbiosis). We want to investigate how dysbiosis influences gut epithelial integrity and the subepithelial immune system. Furthermore we will correlate the local effects of dysbiosis with biomarker profiles, acting as surrogate indicators of gut inflammation and bacterial translocation.