In vivo analysis of the role of a newly identified screenings hit in breast epithelial homeostasis and basal breast cancer progression

01 October 2013 → 30 September 2017
Regional and community funding: Special Research Fund, Research Foundation - Flanders (FWO)
Research disciplines
  • Medical and health sciences
    • Morphological sciences
    • Oncology
    • Morphological sciences
    • Oncology
    • Morphological sciences
    • Oncology
  • Engineering and technology
    • Biomaterials engineering
    • Biological system engineering
    • Biomaterials engineering
    • Biomechanical engineering
    • Other (bio)medical engineering
    • Environmental engineering and biotechnology
    • Industrial biotechnology
    • Other biotechnology, bio-engineering and biosystem engineering
breast cancer EMT biomedical biotechnology molecular biology (cancer) stem cells
Project description

The hit was identified in an siRNA screen as being crucial in ZEB-1 mediated EMT. Transcription factors essential in normal development play an important role in this process. Moreover, studies have shown that EMT is linked with (cancer)stem cells. This suggests an important function for our hit in normal breast development and the progression of basal breast cancer.