Research Explorer

Project

Endothelial glycocalyx damage in chronic kidney disease: the link with uraemic toxins.
Code
3E018615
Duration
01 October 2015 → 30 September 2019
Funding
Research Foundation - Flanders (FWO)
Research disciplines
  • Medical and health sciences
    • Morphological sciences
    • Urology and nephrology
    • Morphological sciences
    • Urology and nephrology
    • Morphological sciences
    • Urology and nephrology
Keywords
Chronic kidney failure uraemic toxins Endothelial glycocalyx
 
Project description
 

Patients with chronic kidney disease have a higher risk of developing cardiovascular diseases. The continuous exposure to uraemic toxins plays an important role in endothelium dysfunction. The mechanisms by which these toxins regulate early stages of endothelial dysfunction remain unclear.
This project will investigate the link between uraemic toxins and damage of the endothelial glycocalyx (the protective endothelial sugar layer).