Research Explorer

Project

Study of the essential function of beta-actin in embryonic development and the necessity of correct localisation of beta-actin mRNA in neuronal development
Code
3F014408
Duration
01 October 2008 → 30 September 2012
Funding
Regional and community funding: Special Research Fund, Research Foundation - Flanders (FWO)
Research disciplines
  • Natural sciences
    • Animal biology
    • Biochemistry and metabolism
    • Genetics
    • Systems biology
  • Medical and health sciences
    • Medical biochemistry and metabolism
    • Morphological sciences
    • Oncology
    • Medical biochemistry and metabolism
    • Morphological sciences
    • Oncology
    • Medical biochemistry and metabolism
    • Morphological sciences
    • Oncology
  • Agricultural and food sciences
    • Veterinary medicine
Keywords
neurogenesis B-actin angiogenesis cell migration actin cytoskeleton
 
Project description

The actin cytoskeleton is the driving force for various cell motility processes. Little is known about the function of the six actin isoforms during mammalian development. During this PhD, we will investigate how loss of beta-actine influences angiogenesis and neurogenesis during embryogenesis and how mislocalisation of beta-actine mRNA leads to aberrant neuronal differentiation and angiogenesis.