Gene and genome duplications are important processes that lead to novel functions and an overall increase in biological complexity. Hence, which genes are preserved following duplication is an important question. Gene families that are shared among angiosperms (core gene families) show consistent differences in preserving duplicated genes (gene duplicability) cross most lineages. Although gene duplicate retention may be explained by various types of selection, dosage constraints could be linked to the retention of duplicated genes. Gene dosage constraint is related to gene dosage sensitivity and gene expression changes following genome duplication. However, the overall effects of gene dosage constraints on gene duplicability of core gene families remain elusive. Here, we propose a project to understand the link between dosage constraints and gene duplicability of core gene families following genome duplication to obtain a deep understanding of duplicated gene retention.