Project

Regulation and function of non-coding RNAs that mediate normal human T cell development.

Duration
01 January 2014 → 31 December 2019
Funding
Research Foundation - Flanders (FWO)
Promotor
Research disciplines
  • Natural sciences
    • Systems biology
  • Medical and health sciences
    • Hematology
    • Immunology
    • Laboratory medicine
    • Palliative care and end-of-life care
    • Regenerative medicine
    • Other basic sciences
    • Hematology
    • Immunology
    • Laboratory medicine
    • Palliative care and end-of-life care
    • Regenerative medicine
    • Other clinical sciences
    • Other health sciences
    • Nursing
    • Other paramedical sciences
    • Hematology
    • Immunology
    • Laboratory medicine
    • Palliative care and end-of-life care
    • Regenerative medicine
    • Other translational sciences
    • Other medical and health sciences
Keywords
hematopoiesis gene regulation T lymphocytes development non-coding RNA
 
Project description

T-lymphocytes are derived from hematopoietic stem cells and their differentiation depends on the integration of multiple transcriptional regulators that modulate downstream gene expression. In this project we investigate, during the process of normal human T-cell development, how these factors interact and what the function is of the non-coding RNAs whose expression they mediate.