Research Explorer

Project

Causes of micro-inflammation and cardiovascular disease in chronic kidney disease: role of uremic peptides
Code
3G016210
Duration
01 January 2010 → 31 December 2015
Funding
Research Foundation - Flanders (FWO)
Research disciplines
  • Natural sciences
    • Biochemistry and metabolism
  • Medical and health sciences
    • Cardiac and vascular medicine
    • Medical biochemistry and metabolism
    • Urology and nephrology
    • Cardiac and vascular medicine
    • Medical biochemistry and metabolism
    • Urology and nephrology
    • Cardiac and vascular medicine
    • Medical biochemistry and metabolism
    • Urology and nephrology
Keywords
cardiovascular diseases uremic retention solutes inflammation
 
Project description
 

Retention of uremic solutes as well as renal replacement therapy contribute to micro-inflammation related to the cardial burden in chronic kidney disease. Especially the effect of uremic peptides on leukocytes and specific leukocyte subpopulations will be evaluated in an in vitro set-up. The pathophysiological mechanisms involved, will be elucidated, aiming at a classification of the retention solutes according to their toxicity.