Research Explorer

Project

Impact of Ly49E receptor expression on tumor immune surveillance in vivo.
Code
365O6710
Duration
01 January 2011 → 31 December 2014
Funding
Funding by bilateral agreement (private and foundations)
Research disciplines
  • Medical and health sciences
    • Immunology
    • Immunology
    • Immunology
Keywords
natural killer epithelial T lymfocytes tumor urokinase plasminogeen activator
 
Project description
 

We will study whether expression of the Ly49E receptor on NK cells and skin intraepithelial T lymphocytes affects their in vivo immune response against tumors. Our hypothesis is that uPA produced by tumor cells is not only advantageous for these cells by promoting their invasion and metastasis, but also because it is used as an escape mechanism from the host innate immune system.