Code
01P14610
Duration
01 October 2010 → 30 September 2013
Funding
Regional and community funding: Special Research Fund
Promotor
Research disciplines
-
Medical and health sciences
- Laboratory medicine
- Medical systems biology
- Physiology
- Laboratory medicine
- Medical systems biology
- Molecular and cell biology
- Physiology
- Laboratory medicine
- Medical systems biology
- Molecular and cell biology
- Physiology
Keywords
pseudoxanthoma elasticum
pathophysiology
vitamin k
therapy
ectopic mineralisation
Project description
Pseudoxanthoma elasticum (PXE) is characterized by soft tissue calcification, the pathophysiological mechanism of which remains unknown. Low serum vitamin K (VK) and inactivated VK-dependent calcification inhibitors in patients suggest a pivotal role for VK in PXE pathogenesis. We will study the role of VK in PXE, identify novel therapeutic targets, and evaluate the therapeutic use of VK supplementation.