Project

Regulation of fibroblast stromagenesis in a three-dimensional tissue-context

Duration
01 October 2007 → 30 September 2011
Funding
Regional and community funding: Special Research Fund, Research Foundation - Flanders (FWO)
Promotor
Research disciplines
  • Medical and health sciences
    • Morphological sciences
    • Oncology
    • Morphological sciences
    • Oncology
    • Morphological sciences
    • Oncology
Keywords
tumor-invasion stromagenesis myofibroblasts
 
Project description

Tumors en their stroma co-evolve during tumor initiation and progression, with proliferation, migration, differentiation and pro-invasive activity of stromal myofibroblasts. The purpose is to study stromagenesis in vitro and in vivo, and to study the influence of soluble cancer-cells derived growth factors as well as to evalute the reaction on chemotherapeutics and ionizing radiation.