Fine tuning of Synthetic Pathways through Conditional Expression for the production of biochemicals

01 January 2013 → 31 December 2018
Research Foundation - Flanders (FWO)
Research disciplines
  • Natural sciences
    • Animal biology
    • Biochemistry and metabolism
  • Medical and health sciences
    • Medical biochemistry and metabolism
    • Medical biochemistry and metabolism
    • Medical biochemistry and metabolism
  • Engineering and technology
    • Catalysis and reacting systems engineering
    • Chemical product design and formulation
    • General chemical and biochemical engineering
    • Process engineering
    • Separation and membrane technologies
    • Transport phenomena
    • Other (bio)chemical engineering
    • Biomaterials engineering
    • Biological system engineering
    • Biomaterials engineering
    • Biomechanical engineering
    • Other (bio)medical engineering
    • Environmental engineering and biotechnology
    • Industrial biotechnology
    • Other biotechnology, bio-engineering and biosystem engineering
metabolic engineering fine tuning expression synthetic biology escherichia coli
Project description

Transfer of multi-gene or poorly understood heterologous pathways into the production host leads to imbalances. Hence, fine tuning the expression of these pathways in specific conditions is mandatory for the succesfull production. This proposal aims to fill the technological and knowledge gap by providing novel metabolic engineering tools allowing fine tuning of complex pathways to enhance production of toxic molecules.