Project

Development of a biotechnological production platform for complex glycans and glycoproteins

Code

01D22215

Duration

01 October 2015 → 30 September 2019

Funding

Regional and community funding: Special Research Fund

Promotor

Wim Soetaert

Fellow

Nico Snoeck

Research disciplines

Engineering and technology
- Biocatalysis and enzyme technology
- Bioprocessing, bioproduction and bioproducts
- Fermentation
- Industrial microbiology
- Industrial biotechnology not elsewhere classified

Keywords

Complex glycans lipopolysaccharides Glycobiotechnology

Project description

The synthesis of complex glycans such as human milk oligosaccharides, which ameliorate infant nutrition, and glycoproteins, important for carbohydrate-vaccines development, requires a new biotechnological production platform. In this project a platform technology will be created that eliminates unwanted glycosylations stemming from the production host’s inherent glycosylation metabolism and modifies the host’s lipopolysaccharide structure to eliminate its endotoxin activity.