Development of a biotechnological production platform for complex glycans and glycoproteins

01 October 2015 → 30 September 2019
Regional and community funding: Special Research Fund
Research disciplines
  • Engineering and technology
    • Biocatalysis and enzyme technology
    • Bioprocessing, bioproduction and bioproducts
    • Fermentation
    • Industrial microbiology
    • Industrial biotechnology not elsewhere classified
Complex glycans lipopolysaccharides Glycobiotechnology
Project description

The synthesis of complex glycans such as human milk oligosaccharides, which ameliorate infant nutrition, and glycoproteins, important for carbohydrate-vaccines development, requires a new biotechnological production platform. In this project a platform technology will be created that eliminates unwanted glycosylations stemming from the production host’s inherent glycosylation metabolism and modifies the host’s lipopolysaccharide structure to eliminate its endotoxin activity.