Project

Development of a biotechnological production platform for complex glycans and glycoproteins

Duration
01 October 2015 → 30 September 2019
Funding
Regional and community funding: Special Research Fund
Research disciplines
  • Engineering and technology
    • Biocatalysis and enzyme technology
    • Bioprocessing, bioproduction and bioproducts
    • Fermentation
    • Industrial microbiology
    • Industrial biotechnology not elsewhere classified
Keywords
Complex glycans lipopolysaccharides Glycobiotechnology
 
Project description

The synthesis of complex glycans such as human milk oligosaccharides, which ameliorate infant nutrition, and glycoproteins, important for carbohydrate-vaccines development, requires a new biotechnological production platform. In this project a platform technology will be created that eliminates unwanted glycosylations stemming from the production host’s inherent glycosylation metabolism and modifies the host’s lipopolysaccharide structure to eliminate its endotoxin activity.