A microfluidics approach towards contact-free laser-induced photoporation for cell-based therapies

01 October 2017 → 30 September 2020
Research Foundation - Flanders (FWO)
Research disciplines
  • Medical and health sciences
    • Biomarker discovery and evaluation
    • Drug discovery and development
    • Medicinal products
    • Pharmaceutics
    • Pharmacognosy and phytochemistry
    • Pharmacology
    • Pharmacotherapy
    • Toxicology and toxinology
    • Other pharmaceutical sciences
  • Engineering and technology
    • Geotechnical and environmental engineering
    • Marine engineering
    • Biological system engineering
    • Biomaterials engineering
    • Biomechanical engineering
    • Medical biotechnology
    • Other (bio)medical engineering
drug delivery biophotonics photoporation microfluidics cell therapy
Project description

Laser-induced photoporation is new technology to efficiently deliver compounds into living cells. Here we address the challenge to photoporate cells without the sensitizing nanoparticles being in direct contact with the cell membrane in order to minimize cell toxicity. The technical realization is based on microfluidics, starting with computer simulations followed by the construction and evaluation of dedicated microfluidic chips.