Project

From gene to aortic dissection - detailed study of the etiology and pathogenesis and of cardiovascular characteristics of inheritable thoracic aortic aneurysms and dissections

Code

01J10213

Duration

01 March 2013 → 31 October 2018

Funding

Regional and community funding: Special Research Fund

Promotor

Julie De Backer

Research disciplines

Natural sciences
- Genetics
- Systems biology
Medical and health sciences
- Molecular and cell biology
- Molecular and cell biology

Keywords

thoracic aortic aneurysm gene expression proteomics TGFbeta pathway

Project description

Aortic aneurysms are associated with significant morbidity and mortality. Study of genetic causes of aortic aneurysms allows us to gain better insights into the underlying pathogenesis and may offer new targets for optimizing treatment. With this project, we aim to search for new genes and gain better insights into the moecualr pathways of aneurysm formation.