Project

Differential effects of androgens and estrogens ont he hyperthrophy and atrophy signals in the aging male skeletal muscle

Duration
01 February 2010 → 30 November 2014
Funding
Regional and community funding: Special Research Fund
Promotor
Research disciplines
  • Medical and health sciences
    • Endocrinology and metabolic diseases
    • Orthopaedics
    • Physiology
    • Endocrinology and metabolic diseases
    • Orthopaedics
    • Physiology
    • Endocrinology and metabolic diseases
    • Orthopaedics
    • Physiology
Keywords
testosterone muscle atrophy sarcopenia
 
Project description

This project aims to investigate the effects of androgens and estrogens on the atrophy and hypertrophy signalling pathways in skeletal muscle of young and aging males. According to the hypothesis, the decline in adrogens in the aging male activates atrophy signals leading to sarcopenia, whereas increased androgen levels will activate the hypertrophy pathways.