Project

Differential effects of androgens and estrogens ont he hyperthrophy and atrophy signals in the aging male skeletal muscle

Code

01N00110

Duration

01 February 2010 → 30 November 2014

Funding

Regional and community funding: Special Research Fund

Promotor

Wim Derave

Research disciplines

Medical and health sciences
- Endocrinology and metabolic diseases
- Orthopaedics
- Physiology
- Endocrinology and metabolic diseases
- Orthopaedics
- Physiology
- Endocrinology and metabolic diseases
- Orthopaedics
- Physiology

Keywords

testosterone muscle atrophy sarcopenia

Project description

This project aims to investigate the effects of androgens and estrogens on the atrophy and hypertrophy signalling pathways in skeletal muscle of young and aging males. According to the hypothesis, the decline in adrogens in the aging male activates atrophy signals leading to sarcopenia, whereas increased androgen levels will activate the hypertrophy pathways.