Study of fatty acid modification and metabolism on the activity of quorum sensing molecules and lipopeptides produced by Pseudomonas spp.

01 October 2012 → 30 September 2016
Regional and community funding: Special Research Fund
Research disciplines
  • Natural sciences
    • Organic chemistry
quorum sensing lipopeptides natural products
Project description

Pseudomonads produce antimicrobial or cytotoxic cyclic lipopeptides (CLPs) and quorum sensing signal molecules, i.e. N-acyl homoserine lactones (AHLs) as interesting secondary metabolites. The overall goal is a) the identification of the role of AHL-mediated quorum sensing mechanisms in regulating secondary metabolite production (CLPs) and b) the elucidtation of fatty acid-based biosynthetic pathways and SAR of CLPs.