Synthesis of diamino acid derivatives with a cyclopropane or aziridine skeleton and their application in the synthesis of potential physiologically active alpha,gamma-diaminobutyric acid derivates

01 January 2009 → 31 December 2014
Research Foundation - Flanders (FWO)
Research disciplines
  • Natural sciences
    • Organic chemistry
    • Other chemical sciences
  • Agricultural and food sciences
    • Agricultural plant production
nonproteinogenic amino acids cyclopropanes aziridines
Project description

The synthesis of constrained A, B- or A, Y-diamino acid derivatives as building blocks for new substituted 2,4-diaminobutyric acid derivatives is of great importance in medicinal and agricultural chemisrty. This research concerns the development of stereoselective syntheses and biochemical evaluation of new derivatives of 1,2-diaminocyclopropane-1-carboxylic acid and also the stufdy of their ring opening reactions towards potentially physiologically active amino acid derivatives.