Project

Structure-function analysis of the human paracaspase MALT1 in antigen receptor induced signal transduction to NF-kB dependent gene expression

Duration
01 October 2008 → 30 September 2014
Funding
Regional and community funding: Special Research Fund, Research Foundation - Flanders (FWO)
Research disciplines
  • Natural sciences
    • Biochemistry and metabolism
    • Systems biology
  • Medical and health sciences
    • Immunology
    • Medical biochemistry and metabolism
    • Immunology
    • Medical biochemistry and metabolism
    • Immunology
    • Medical biochemistry and metabolism
Keywords
proteolytic activity NF-kB signal transduction
 
Project description

The paracaspase MALT1 plays an important role in activation of NF-kB through T- and B-cell receptors. The aims of this project are: 1) To identifty new substrates for MALT1 and to characterize their role. 2) To identify the molecular mechanisms that regulate MALT1 proteolytic activity.