Project

Connexin-mediated bystander responses in radiation-induced damage of brain endothelial cells

Duration
01 October 2012 → 30 September 2018
Funding
Regional and community funding: Special Research Fund, Research Foundation - Flanders (FWO)
Research disciplines
  • Medical and health sciences
    • Immunology
    • Physiology
    • Immunology
    • Physiology
    • Immunology
    • Physiology
Keywords
intercellular communication inflammation connexins endothelial cells cell death
 
Project description

The aim is to elucidate mechanisms of intercellular communication via connexins in radiation-induced cell death and inflammation in the context of glioma radiotherapy. We particularly focus on brain endothelial cells, which are known to be highly radiosensitive and are extensively coupled through connexin channels. Furthermore, the consequences of endothelial bystander responses for tumor cells and normal tissue will be analyzed.