Research Explorer

Project

Use of an integrative classification system and next-generation sequencing strategies for gene identification in common variable immunodeficiency disorder (CVID).
Code
3F002513
Duration
01 October 2013 → 30 September 2017
Funding
Regional and community funding: Special Research Fund, Research Foundation - Flanders (FWO)
Research disciplines
  • Medical and health sciences
    • Immunology
    • Laboratory medicine
    • Palliative care and end-of-life care
    • Regenerative medicine
    • Other basic sciences
    • Immunology
    • Laboratory medicine
    • Palliative care and end-of-life care
    • Regenerative medicine
    • Other clinical sciences
    • Other health sciences
    • Nursing
    • Other paramedical sciences
    • Immunology
    • Laboratory medicine
    • Palliative care and end-of-life care
    • Regenerative medicine
    • Other translational sciences
    • Other medical and health sciences
Keywords
genetic classification Common variable immunodeficiency disorder (CVID)
 
Project description

Common variable immunodeficiency disorder (CVID) is a group of diseases charachterized by a decrease in immunoglobulines and in number and/or function of B-lymphocyte subsets. Its heterogeneity complicates the elucidation of underlying disease mechanisms and gene defects.

This study aims to develop a classification of CVID patients integrating clinical data, immunophenotyping, molecular analyses and next-generation sequencing, in order to discover(new)gene defects.