Project

Glucocorticoid and selective glucocorticoid receptor modulator effects on the tumor eco-system : dissociating the mechanism

Duration
01 November 2011 → 17 June 2014
Funding
Regional and community funding: Special Research Fund
Promotor
Research disciplines
  • Natural sciences
    • Biochemistry and metabolism
  • Medical and health sciences
    • Medical biochemistry and metabolism
    • Morphological sciences
    • Oncology
    • Medical biochemistry and metabolism
    • Morphological sciences
    • Oncology
    • Medical biochemistry and metabolism
    • Morphological sciences
    • Oncology
Keywords
cancer SGRM glucocorticoids invasion
 
Project description

Tumor metastases can only form succesfully upon invasion of the primary tumor's surrounding tissue. Glucocorticoids (GCs) and selective glucocorticoid receptor modulators (SGRMs) can inhibit invasion via a largely unknown mechanism. In this project we study the effects of GCs and SGRMs on invasion-associated proteins and screen for new targets in the regulation of invasion mechanisms.