Research Explorer

Project

Functional implication and prognostic significance of the WISP-2 matricellular protein in breast cancer-and trophoblast invasion
Code
31505209
Duration
01 January 2009 → 30 December 2011
Funding
Research Foundation - Flanders (FWO)
Promotor
Research disciplines
  • Medical and health sciences
    • Morphological sciences
    • Oncology
    • Morphological sciences
    • Oncology
    • Morphological sciences
    • Oncology
Keywords
matricellular invasion breast cancer
 
Project description
 

Matricellular proteins such as the Wnt-induced secreted proteine, WISP-2 is implicated in carcinoma cell invasion (Fritah et al., 2008). The functional and prognostic role of WISP-2 in breast cancer is not known. We make use of cellular models to screen for fysiological inhibitors of WISP-2 mediated invasion with a focus on basal membrane components such as laminin and nidogen. Human breast tumor tissue will be analysed by Q-PCR and immunohistochemistry.