Matricellular proteins such as the Wnt-induced secreted proteine, WISP-2 is implicated in carcinoma cell invasion (Fritah et al., 2008). The functional and prognostic role of WISP-2 in breast cancer is not known. We make use of cellular models to screen for fysiological inhibitors of WISP-2 mediated invasion with a focus on basal membrane components such as laminin and nidogen. Human breast tumor tissue will be analysed by Q-PCR and immunohistochemistry.