Project

Interleukin-34: an exciting new twist in the activation of the human Colony Stimulating Factor 1 Receptor

Acronym
Interleukine-34
Duration
01 January 2010 → 31 December 2015
Funding
Research Foundation - Flanders (FWO)
Research disciplines
  • Natural sciences
    • Analysis
    • Medicinal and biomolecular chemistry
    • Molecular and cell biology
    • Plant biology
    • Systems biology
  • Medical and health sciences
    • Biophysics
    • Immunology
    • Molecular and cell biology
    • Biophysics
    • Immunology
    • Molecular and cell biology
    • Biophysics
    • Immunology
    • Molecular and cell biology
Keywords
structural biology protein-protein interaction immune system hematopoiesis
 
Project description

We propose an interdisciplinary research project at the frontline of molecular structural biology to dissect the interaction of a novel cytokine, interleukin-34 (IL-34), with its hematopoietic receptor tyrosine kinase III (RTKIII) receptor, Colony Stimulating Factor-1 Receptor (CSF-1R of c-fms). The proposed research project aims to provide important new insights into the structural, kinetic and thermodynamic determinants that dicate this unusual cytokine-receptor specificty.