Project

Investigation of the mechanism of immune protection evoked by a novel RSV vaccine candidate based on the ectodomain of the small hydrophobic protein.

Duration
01 January 2012 → 31 December 2014
Funding
Research Foundation - Flanders (FWO)
Research disciplines
  • Natural sciences
    • Genetics
  • Medical and health sciences
    • Vaccinology
    • Pathophysiology
    • Adaptive immunology
    • Molecular and cell biology not elsewhere classified
Keywords
Respiratory syncytial virus vaccine immune mechanism Small Hydrophobic protein
 
Project description

We recently developed a novel vaccine based on the ectodomain of the RSV small hydrophobic protein. The aim of this project is to elucidate the mechanism by which SHe based vaccination protects against RSV infections. As SHe specific immune serum or monoclonal antibodies do not neutralize RSV infection in vitro, we will investigate the role of immune cells in vaccination induced immunity in vivo. More specifically we will investigate the potential involvement of T cell immunity and antibody dependent killing of infected cells by Macrophages or NK cells.