Project

Mechanistic study on the prediction of the pharmacokinetics of drugs in children

Duration
01 January 2012 → 31 December 2016
Funding
Regional and community funding: Special Research Fund
Research disciplines
  • Medical and health sciences
    • Biomarker discovery and evaluation
    • Drug discovery and development
    • Medicinal products
    • Pharmaceutics
    • Pharmacognosy and phytochemistry
    • Pharmacology
    • Pharmacotherapy
    • Toxicology and toxinology
    • Other pharmaceutical sciences
Keywords
PBPK-modelling pharmacokinetics paediatric drug development
 
Project description

This project aims to evaluate the usefulness of Physiologically Based Pharmacokinetic (PBKP) - Modelling in predicting the pharmacokinetics of drugs en paediatric populations. Current knowledge on PBPK-modelling in children will be expanded, an the resulting model will be tested and validated using the model drugs tramadol and propofol.