Research Explorer

Project

Selective photoporation of the nuclear envelope to mimic pathological defects and facilitate intranuclear delivery.
Code
01SC1722
Duration
01 October 2022 → 30 September 2026
Funding
Regional and community funding: Special Research Fund
Research disciplines
  • Natural sciences
    • Nanochemistry
    • Optical properties of materials
  • Medical and health sciences
    • Nucleic acids
    • Cancer therapy
    • Pathophysiology
Keywords
photoporation intranuclear delivery nuclear envelope laminopathies
 
Project description
 

Here, we intend to develop a laser-nanoparticle approach, called photoporation, to controllably induce transient permeabilization of the nuclear envelope in living cells. This will allow to mimic pathological defects which lead to laminopathies and enhance intranuclear delivery of gene editing compounds.