This project “dsRNA+virus” has two keywords: RNA interference (RNAi) and virus. First, RNAi is an advanced and specific post-transcriptional gene silencing method; its discovery resulted in the Nobel Prize in Physiology and Medicine in 2006, and during this first RNAi decade, scientists recognize its potential for useful applications, including crop protection. Second, viruses as pest pathogens have a long time interest for the biological control of important pests in agriculture, but their development is hampered by the limitation of virus discovery. The main objective of this project is as follows: through investigation of pest virus and RNAi in silencing immune-related genes, the project is proposed to take the advantage of the synergy of “RNAi” and “virus”, and so to construct a new model for agricultural pest control with the combination of biotechnology “RNAi” and biological control agent “virus”. This new, non-transgenic plant approach aims to help in the control pest insects and mites in a modern agriculture, and so to reduce the use of detrimental pesticides in our efforts to provide a growing population with safe, abundant food.