Code
01D22407
Duration
01 October 2007 → 01 October 2008
Funding
Regional and community funding: Special Research Fund
Promotor
Research disciplines
-
Natural sciences
- Animal biology
- Biochemistry and metabolism
- Genetics
- Systems biology
-
Medical and health sciences
- Medical biochemistry and metabolism
- Morphological sciences
- Medical biochemistry and metabolism
- Morphological sciences
- Medical biochemistry and metabolism
- Morphological sciences
-
Agricultural and food sciences
- Veterinary medicine
Keywords
actin isoforms
embryonic development
cytoskeleton
Project description
Through analysis of the B-actin knock-out en knock-in mice, and derived cell lines thereof, we will study the essential functions of B-actin in development (more specific in vascularisation and neuronal differentiation) and the role of the 3'UTR in correct localization and function of B-actin. Several methods will be used, including in situ immunostaining, primary cell cultures, RNAi and differential proteome analysis.